Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis
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چکیده
منابع مشابه
Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis
Infectious disease burden remains high [1]. An improved knowledge of host–microorganism interactions is key to delineating disease progression and developing new control and treatment modalities. Microorganisms may be pathogenic (able to cause disease) or non-pathogenic (unable to cause disease). Disease severity is influenced by host and pathogen factors; in particular, pathogens may express d...
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From the Division of General and Community Pediatrics (Drs Real, Beck, and Klein), Division of Hospital Medicine (Drs Beck and Klein), Cincinnati Children’s Hospital Medical Center, Ohio; and Division of General Pediatrics, Boston Medical Center (Dr Michelson), Mass The authors have no conflicts of interest to disclose. Address correspondence to Francis J. Real, MD, 3333 Burnet Ave, MLC 2011, C...
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The reasons why some DNA replication origins fire earlier than others have remained elusive. New work by Gindin et al suggests that the distribution of replication origins, not their timing per se, is the major determinant of the timing of genome replication in human cells.
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Assumptions on a likelihood function, including a local GlivenkoCantelli condition, imply the existence of M-estimators converging to an Mfunctional. Scatter matrix-valued estimators, defined on all empirical measures on R for d ≥ 2, and equivariant under all, including singular, affine transformations, are shown to be constants times the sample covariance matrix. So, if weakly continuous, they...
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Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2016
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1005519